Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the c-kit receptor

Int Arch Allergy Immunol. May-Jun 1995;107(1-3):51-3. doi: 10.1159/000236928.

Abstract

Stem cell factor (SCF), the ligand for the receptor (SCFR) that is encoded by the c-kit proto-oncogene, has many important effects in mouse and human mast cell development, survival, and function. SCF can promote mast cell survival by suppressing apoptosis, induce mast cell hyperplasia in murine rodents, experimental primates and humans, directly induce SCFR-dependent mast cell mediator release, and significantly modulate the extent of mast cell activation by Fc epsilon RI-dependent mechanisms. These findings raise several clinical issues and, in some cases, point to potentially significant therapeutic opportunities.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Survival
  • Hematopoietic Cell Growth Factors / genetics
  • Hematopoietic Cell Growth Factors / physiology*
  • Humans
  • Hyperplasia
  • Macaca fascicularis
  • Mast Cells / cytology*
  • Mice
  • Papio
  • Proto-Oncogene Proteins / biosynthesis
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-bcl-2
  • Proto-Oncogene Proteins c-kit
  • Rats
  • Receptor Protein-Tyrosine Kinases / physiology*
  • Receptors, Colony-Stimulating Factor / physiology*
  • Receptors, IgE / physiology
  • Stem Cell Factor

Substances

  • Hematopoietic Cell Growth Factors
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Receptors, Colony-Stimulating Factor
  • Receptors, IgE
  • Stem Cell Factor
  • Proto-Oncogene Proteins c-kit
  • Receptor Protein-Tyrosine Kinases