Taxol encapsulation in poly(epsilon-caprolactone) microspheres

Cancer Chemother Pharmacol. 1995;36(4):279-82. doi: 10.1007/BF00689043.


Poly(epsilon-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allantois / blood supply
  • Animals
  • Chick Embryo
  • Chorion / blood supply
  • Delayed-Action Preparations
  • Microspheres
  • Neovascularization, Pathologic / prevention & control
  • Paclitaxel / administration & dosage*
  • Paclitaxel / pharmacokinetics
  • Paclitaxel / pharmacology
  • Polyesters*


  • Delayed-Action Preparations
  • Polyesters
  • polycaprolactone
  • Paclitaxel