Rho as a regulator of the cytoskeleton

Trends Biochem Sci. 1995 Jun;20(6):227-31. doi: 10.1016/s0968-0004(00)89022-2.


Many cell functions, including maintenance of morphology, aggregation, motility, membrane ruffling, smooth-muscle contraction, cytokinesis in mammals and bud formation in yeast, are regulated through the dynamic reorganization of actin filaments. Although it has long been known that Ca2+ is a key regulator of the cytoskeleton, evidence is now accumulating that Rho, a Ras-related small GTP-binding protein, is another important regulator of these actin-dependent cell functions.

Publication types

  • Review

MeSH terms

  • Acute-Phase Proteins / physiology*
  • Cytoskeleton / physiology*
  • Protein Structure, Tertiary


  • Acute-Phase Proteins
  • acute-phase protein rho