The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA

Trends Biochem Sci. 1995 Jun;20(6):235-40. doi: 10.1016/s0968-0004(00)89024-6.


The RNP domain is found in a number of proteins involved in processing and transport of mRNA precursors. The crystal structure of a complex between the U1A spliceosomal protein and its cognate RNA hairpin at 1.92 A resolution reveals the molecular basis of sequence-specific RNA recognition by the RNP domain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Biological Transport
  • Molecular Sequence Data
  • Protein Structure, Tertiary*
  • RNA / metabolism*
  • RNA Processing, Post-Transcriptional*
  • RNA-Binding Proteins / chemistry*
  • Ribonucleoproteins / chemistry*


  • RNA-Binding Proteins
  • Ribonucleoproteins
  • RNA