Diagnostic significance of prostate specific antigen and the development of a mass screening system for prostate cancer

J Urol. 1995 Sep;154(3):1085-9.


Purpose: The significance of prostate specific antigen (PSA) in the mass screening for prostate cancer was investigated.

Materials and methods: A total of 4,375 PSA, digital rectal and transrectal ultrasonographic examinations was performed on 3,526 subjects.

Results: Among the 3 modalities, PSA had the highest sensitivity (80.4%) and positive predictive value (45.1%). We established age-specific reference PSA ranges for normal Japanese men, and demonstrated the significance of PSA density and PSA velocity.

Conclusions: The significance of PSA as a prostate cancer screening modality should be evaluated across multiple age ranges and in combination with previous PSA data and/or prostate volume.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Humans
  • Male
  • Mass Screening / methods*
  • Middle Aged
  • Palpation
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / diagnostic imaging
  • Sensitivity and Specificity
  • Ultrasonography


  • Prostate-Specific Antigen