Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs

Gene. 1995 Jul 28;160(2):297-302. doi: 10.1016/0378-1119(95)00216-s.

Abstract

Reduced-stringency PCR was used to isolate a cDNA encoding a novel human FK506-binding protein (FKBP) homolog. The encoded 38-kDa protein (FKBPr38) contains at its N-terminus a domain that is 33% identical to FKBP12. FKBPr38 is a member of a subclass of immunophilins, whose other members include FKBP52 and CyP40 (cyclophilin 40), that contain a three-unit tetratricopeptide repeat (TPR). In addition, FKBPr38 contains a consensus leucine-zipper repeat. The presence of the TPR domain and leucine zipper suggest that FKBPr38 may form homo-multimers or interact with other, as yet unidentified, proteins.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Isomerases / genetics
  • Amino Acid Sequence
  • Base Sequence
  • Binding Sites
  • Calmodulin / metabolism
  • Carrier Proteins / genetics*
  • Consensus Sequence
  • Cyclophilins*
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / genetics*
  • Genes*
  • Heat-Shock Proteins / genetics*
  • Humans
  • Leucine Zippers* / genetics
  • Molecular Sequence Data
  • Peptidyl-Prolyl Isomerase F
  • Peptidylprolyl Isomerase*
  • Polymerase Chain Reaction
  • Repetitive Sequences, Nucleic Acid*
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Tacrolimus / metabolism
  • Tacrolimus Binding Proteins

Substances

  • Calmodulin
  • Carrier Proteins
  • Peptidyl-Prolyl Isomerase F
  • DNA, Complementary
  • DNA-Binding Proteins
  • Heat-Shock Proteins
  • Amino Acid Isomerases
  • Cyclophilins
  • Tacrolimus Binding Proteins
  • Peptidylprolyl Isomerase
  • Tacrolimus

Associated data

  • GENBANK/L37033