Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 15 (4), 1491-9

Biochemical Characteristics and Clinical Applications of Alpha-Fetoprotein Isoforms

Affiliations
  • PMID: 7544570
Review

Biochemical Characteristics and Clinical Applications of Alpha-Fetoprotein Isoforms

E Seregni et al. Anticancer Res.

Abstract

Alphafetoprotein (AFP) is an oncofetal glycoprotein that frequently reappears in sera of patients affected by hepatocellular carcinoma (HCC) and yolk-sac tumours (YST). In these cases AFP determination represents a useful marker for monitoring the therapeutic response and the clinical evolution of the neoplastic disease. AFP is a heterogeneous molecule with respect to the carbohydrate moiety and the different AFP glycoforms can be separated and characterized by their affinity for lectins, such as Concanavalin A (con A), and Lens culinaris agglutinin (LCA). Increased production of LCA-reactive AFP has been proposed as a specific and early marker for HCC, while Con A non-reactive AFP could be a marker for YST and gastrointestinal malignancies. In this review the molecular basis of AFP microheterogeneity and the clinical application of AFP isoforms will be discussed.

Similar articles

See all similar articles

Cited by 4 PubMed Central articles

Publication types

LinkOut - more resources

Feedback