Abstract
Esterase activity of endogenous transiently expressed acetylcholinesterase was locally suppressed in visual cortex of infant rats for 2-5 days by the irreversible inhibitor phospholine iodide, delivered from Elvax implants. Tissue processed for anterograde movement of the carbocyanine dye DiI or anterograde transneuronal transport of wheat germ agglutinin-horseradish peroxidase revealed normal geniculocortical growth into layer IV of visual cortex. These results suggest that the catalytic activity of transiently expressed acetylcholinesterase may play little, if any, role in early development of thalamocortical systems.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Animals, Newborn / growth & development*
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Carbocyanines
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Cholinesterase Inhibitors / pharmacology*
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Echothiophate Iodide / pharmacology
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Female
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Fluorescent Dyes
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Geniculate Bodies / drug effects
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Geniculate Bodies / growth & development*
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Horseradish Peroxidase
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Male
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Neural Pathways / drug effects
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Neural Pathways / growth & development
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Polyvinyls / metabolism
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Rats
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Rats, Sprague-Dawley
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Visual Cortex / drug effects
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Visual Cortex / growth & development*
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Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
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Wheat Germ Agglutinins
Substances
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Carbocyanines
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Cholinesterase Inhibitors
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Fluorescent Dyes
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Polyvinyls
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Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
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Wheat Germ Agglutinins
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ethylenevinylacetate copolymer
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3,3'-dioctadecylindocarbocyanine
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Echothiophate Iodide
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Horseradish Peroxidase