Abstract
The effects of a non-steroidal anti-inflammatory drug, flurbiprofen, and its nitro-derivative, nitroflurbiprofen, on inducible nitric oxide synthase in rat neutrophils were examined. Nitroflurbiprofen was shown to inhibit nitric oxide synthase induction caused by lipopolysaccharide administration, while flurbiprofen had no effect on nitric oxide synthase induction. This inhibitory action may be ascribed to nitric oxide released from nitroflurbiprofen.
MeSH terms
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Administration, Oral
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Amino Acid Oxidoreductases / biosynthesis*
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Analysis of Variance
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Cell Separation
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Centrifugation, Density Gradient
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Enzyme Induction / drug effects
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Female
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Flurbiprofen / analogs & derivatives*
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Flurbiprofen / pharmacology*
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Lipopolysaccharides / toxicity
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Neutrophils / drug effects*
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Neutrophils / enzymology
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Nitrates / blood
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Nitric Oxide Synthase
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Nitrites / blood
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Rats
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Rats, Sprague-Dawley
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lipopolysaccharides
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Nitrates
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Nitrites
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nitroflurbiprofen
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Flurbiprofen
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Nitric Oxide Synthase
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Amino Acid Oxidoreductases