Depletion of myelin-basic-protein autoreactive T cells by T-cell vaccination: pilot trial in multiple sclerosis

Lancet. 1995 Sep 23;346(8978):807-8. doi: 10.1016/s0140-6736(95)91622-9.

Abstract

In a pilot trial, eight patients with multiple sclerosis were matched to control patients and received T-cell vaccination with irradiated T cells reactive to myelin basic protein (MBP) to deplete circulating MBP-reactive T cells. In the 2 years before and after vaccination, exacerbations decreased in five vaccinated patients (numbers 1, 2, 6-8) with relapsing-remitting disease from sixteen to three, respectively, and from twelve to ten in their matched controls. Magnetic resonance imaging showed a mean 8.0% increase in brain lesion size in the vaccinated patients compared with a 39.5% increase in the controls. Lesions and/or relapses worsened in three cases after vaccination in association with reappearance of circulating MBP-reactive T cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autoimmunity*
  • Brain / pathology
  • Case-Control Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Lymphocyte Depletion
  • Magnetic Resonance Imaging
  • Male
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis / pathology
  • Multiple Sclerosis / therapy*
  • Myelin Basic Protein / immunology*
  • Pilot Projects
  • Recurrence
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / radiation effects
  • Vaccination*
  • Vaccines

Substances

  • Myelin Basic Protein
  • Vaccines