The origin of CD4-CD8-TCR alpha beta+ thymocytes: a model based on T-cell receptor avidity

Immunol Today. 1995 Sep;16(9):428-31. doi: 10.1016/0167-5699(95)80019-0.


Ralph Budd and Philip Mixter present a hypothesis suggesting that CD4-CD8-TCR alpha beta+ cells arising in the normal thymus result from a high-avidity T-cell receptor (TCR) signal bordering on negative selection. In normal mice, this subset is likely to be gradually deleted but, in the absence of Fas, these cells persist in lpr mice. The model they describe makes several predictions regarding the nature of this unusual T-cell subset.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • CD4 Antigens / metabolism
  • CD8 Antigens / metabolism
  • Mice
  • Mice, Transgenic
  • Models, Biological*
  • Phenotype
  • Receptors, Antigen, T-Cell, alpha-beta / immunology*
  • T-Lymphocyte Subsets / immunology*


  • CD4 Antigens
  • CD8 Antigens
  • Receptors, Antigen, T-Cell, alpha-beta