Intrathymic and extrathymic clonal deletion of T cells

Curr Opin Immunol. 1995 Apr;7(2):196-205. doi: 10.1016/0952-7915(95)80004-2.


Clonal elimination accounts for self-tolerance induction in the thymus and also affects mature T cells responding to exogenous antigens in the periphery. Recent evidence on the microenvironments, cell-cell interactions and signalling requirements for clonal deletion of immature and mature T cells is discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Clonal Deletion / immunology*
  • T-Lymphocytes / immunology*
  • Thymus Gland / immunology*