Somatic hypermutation

Curr Opin Immunol. 1995 Apr;7(2):248-54. doi: 10.1016/0952-7915(95)80010-7.


For the generation of secondary response antibodies, immunoglobulin genes are subjected to hypermutation. Cells expressing antibodies with higher affinity are then selected by antigen. Recent clues to the mechanism of hypermutation come from experiments using transgenic mice enabling analysis of the controlling cis-acting elements and the intrinsic features of the hypermutation, dissociated from the effects of antigenic selection.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • Genes, Immunoglobulin*
  • Humans
  • Immunoglobulin Variable Region / genetics*
  • Mice
  • Mutation*


  • Immunoglobulin Variable Region