Single T cell probes for antigen/MHC expression

Curr Opin Immunol. 1995 Apr;7(2):258-62. doi: 10.1016/0952-7915(95)80012-3.


T-cell receptor binding to the antigen/MHC ligand on the surface of antigen-presenting cells is the central event in T-cell activation. Methods have been developed for measuring this recognition event in single T cells and have allowed their use as 'probes' for antigen/MHC expression. Single cell assays have allowed analysis of early events in T-cell activation, and of unknown ligands recognized by the T-cell receptor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Humans
  • Molecular Probes / immunology*
  • Receptors, Antigen, T-Cell / analysis*
  • T-Lymphocytes / chemistry*


  • Molecular Probes
  • Receptors, Antigen, T-Cell