The cell biology of CTL killing

Curr Opin Immunol. 1995 Jun;7(3):343-8. doi: 10.1016/0952-7915(95)80108-1.


A great deal is known about the immunology of cytotoxic T lymphocyte killing, but much less is known about the cell biology of this process. Recent work has begun to elucidate the mechanisms that control lytic-protein secretion, and reveals that some unusual features of these secretory processes might explain some of the important features of killing by cytotoxic T lymphocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Apoptosis
  • Cell Communication / immunology
  • Cytoplasmic Granules
  • Cytotoxicity, Immunologic
  • Endocytosis
  • Epitopes
  • Humans
  • Models, Immunological
  • Organelles / immunology
  • Organelles / physiology
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / physiology
  • Signal Transduction
  • T-Lymphocytes, Cytotoxic / immunology*
  • T-Lymphocytes, Cytotoxic / physiology


  • Epitopes
  • Receptors, Antigen, T-Cell