Mouse NK1+ T cells

Curr Opin Immunol. 1995 Jun;7(3):367-74. doi: 10.1016/0952-7915(95)80112-x.


Mouse NK1+ T cells constitute a special subset of alpha beta TCR+ T cells that express natural killer surface receptors and are thought to play an immunoregulatory role because of their unique ability to secrete IL-4 within minutes of primary activation. The recent discovery that they recognize non-polymorphic MHC class I like ligands encoded by CD1 family genes sheds a new light on unusual aspects of their development as well as on some of the possible ways in which they might influence the regulation of the T-helper cell (types 1 and 2) classes of immune responses.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD1 / immunology
  • Base Sequence
  • CD4-Positive T-Lymphocytes / immunology
  • Epitopes
  • Histocompatibility Antigens Class I / immunology
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / physiology
  • Lymphocyte Activation
  • Mice / immunology*
  • Mice, Inbred Strains
  • Mice, Knockout
  • Mice, Nude
  • Mice, Transgenic
  • Models, Immunological
  • Molecular Sequence Data
  • Phenotype
  • Receptors, Antigen, T-Cell, alpha-beta / genetics
  • Receptors, Antigen, T-Cell, alpha-beta / immunology
  • Spleen / immunology
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / physiology
  • Thymus Gland / immunology


  • Antigens, CD1
  • Epitopes
  • Histocompatibility Antigens Class I
  • Receptors, Antigen, T-Cell, alpha-beta