Molecular mechanisms underlying functional T-cell unresponsiveness

Curr Opin Immunol. 1995 Jun;7(3):375-81. doi: 10.1016/0952-7915(95)80113-8.


Evidence from tissue culture experiments and in vivo studies indicates that certain forms of antigen presentation render T cells unresponsive to subsequent antigenic stimulation. Great progress has been made recently in understanding the induction, maintenance, and in vivo relevance of this unresponsive state, called clonal anergy.

Publication types

  • Review

MeSH terms

  • Animals
  • Cells, Cultured
  • Humans
  • Immune Tolerance
  • Immunocompetence*
  • Interleukin-2 / biosynthesis
  • Interleukin-2 / immunology
  • Mice
  • Mice, Transgenic
  • Models, Immunological
  • Signal Transduction / immunology
  • T-Lymphocytes / immunology*


  • Interleukin-2