Activation-induced death of mature T cells in the regulation of immune responses

Curr Opin Immunol. 1995 Jun;7(3):382-8. doi: 10.1016/0952-7915(95)80114-6.


Deletion of self-reactive clones of immature thymocytes by activation-induced death (AID) is thought to be the primary mechanism for the establishment of self-tolerance in the T-cell compartment. Recent evidence suggests that a genetically distinct but analogous process of AID in mature T cells is important in regulating peripheral immune responses. AID of peripheral T cells requires the expression of functional Fas and Fas ligand by the T-cell population. As qualitatively similar signals from the TCR are responsible for both T-cell expansion in inflammation and T-cell elimination by AID, regulating the balance between these opposing functions plays a crucial role in successful responses to pathogens and tumors while minimizing autoimmunity.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation / immunology
  • Antigen Presentation / physiology
  • Apoptosis*
  • CD28 Antigens / immunology
  • CD28 Antigens / physiology
  • Cytokines / immunology
  • Cytokines / physiology
  • Cytotoxicity, Immunologic
  • Ligands
  • Lymphocyte Activation*
  • Mice
  • Mice, Inbred Strains
  • Models, Immunological
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / physiology
  • Th1 Cells / immunology
  • Th1 Cells / physiology
  • fas Receptor / immunology
  • fas Receptor / physiology


  • CD28 Antigens
  • Cytokines
  • Ligands
  • fas Receptor