Acidogenicity of high-intensity sweeteners and polyols

Am J Dent. 1995 Feb;8(1):23-6.


Purpose: To evaluate the plaque pH responses to sucrose, fructose, xylitol, sorbitol, acesulfame-K, aspartame, and saccharin at equal sweetness levels (equivalent to 10% sucrose) and water using an indwelling plaque pH telemetry system.

Materials and methods: Eight adult panelists used each sweetener once in a Latin square study design. Plaque was allowed to accumulate for 3-6 days before each challenge period, and the panelists fasted for 12 hours prior to the 2-minute test rinse. Plaque pH was monitored for a 2-hour period after the rinse exposure. The parameters examined were area of the curves under pH 5.5 (pH X Time), pH changes from baseline, lowest pH attained and time below pH 5.5.

Results: The the high-intensity sweeteners (aspartame, saccharin and acesulfame-K) and the polyols (sorbitol and xylitol) were all non-acidogenic and were not significantly different from each other while both sucrose and fructose were highly acidogenic.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Analysis of Variance
  • Aspartame / pharmacology
  • Dental Plaque / chemistry*
  • Dental Plaque / metabolism*
  • Diet, Cariogenic
  • Fructose / pharmacology
  • Humans
  • Hydrogen-Ion Concentration / drug effects
  • Middle Aged
  • Saccharin / pharmacology
  • Sorbitol / pharmacology
  • Sucrose / pharmacology
  • Sweetening Agents / pharmacology*
  • Thiazines / pharmacology
  • Xylitol / pharmacology


  • Sweetening Agents
  • Thiazines
  • Fructose
  • Sorbitol
  • Sucrose
  • Saccharin
  • acetosulfame
  • Xylitol
  • Aspartame