Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development

Mech Dev. 1995 Jun;51(2-3):341-50. doi: 10.1016/0925-4773(95)00383-5.


The Wnt gene family encodes a set of signalling molecules implicated in the development of a wide range of organisms. We have recently cloned partial cDNA sequences of murine Wnt-11 and Wnt-12. Here, we describe the spatio-temporal expression patterns of both genes during mouse embryogenesis. Wnt-11 expression is first detected within the truncus arteriosus from 8.25 dpc. By 9.5 dpc, Wnt-11 expression is detected in the somites at the medial junction of the dermatome and the myotome. Wnt-11 transcripts are also detected in limb bud mesenchyme from the time the bud is first visible. Wnt-12 is detected in the apical ectodermal ridge from 10.5 dpc. The implications of these expression patterns are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary / genetics
  • Embryonic and Fetal Development / genetics*
  • Female
  • Gene Expression Regulation, Developmental*
  • Glycoproteins*
  • In Situ Hybridization
  • Mice
  • Mice, Inbred ICR
  • Molecular Sequence Data
  • Pregnancy
  • Proteins / genetics*
  • Proto-Oncogene Proteins*
  • Reading Frames
  • Sequence Homology, Amino Acid
  • Wnt Proteins


  • DNA, Complementary
  • Glycoproteins
  • Proteins
  • Proto-Oncogene Proteins
  • Wnt Proteins
  • Wnt10b protein, mouse

Associated data

  • GENBANK/X70800