Self-treatment of female external genital warts with 0.5% podophyllotoxin cream (Condyline) vs weekly applications of 20% podophyllin solution

Int J STD AIDS. 1995 Jul-Aug;6(4):257-61. doi: 10.1177/095646249500600407.


Sixty women with genital warts were randomly allocated to treatment with either weekly application of 20% podophyllin solution or self-treatment with 0.5% podophyllotoxin cream twice daily for three days in weekly intervals. After a maximum of 4 treatment cycles a final assessment was carried out after 3 months. Primary clearance after termination of treatment was 82% for podophyllotoxin and 59% for podophyllin solution. After excluding relapses at the 3-month follow-up, final clearance for podophyllotoxin (71%) was significantly better (P < 0.05) than that for podophyllin solution (48%). The total frequency of warts eradicated was 94% with podophyllotoxin and 74% with podophyllin solution (P < 0.001). Local adverse effects were generally mild or moderate. Podophyllotoxin cream provides a mode of easy application for women with external genital warts and had in this study a significantly better effect than podophyllin solution.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Condylomata Acuminata / drug therapy*
  • Female
  • Follow-Up Studies
  • Genital Diseases, Female / drug therapy*
  • Humans
  • Keratolytic Agents / therapeutic use*
  • Middle Aged
  • Ointments
  • Podophyllin / therapeutic use*
  • Podophyllotoxin / therapeutic use*
  • Recurrence
  • Solutions


  • Keratolytic Agents
  • Ointments
  • Solutions
  • Podophyllin
  • Podophyllotoxin