Induction of apoptosis by tumor suppressor genes and oncogenes

Semin Cancer Biol. 1995 Feb;6(1):17-25. doi: 10.1006/scbi.1995.0003.

Abstract

The p53 tumor suppressor gene product, and the bcr-abl, bcl-2, and c-myc gene products all appear to influence the susceptibility of cells to apoptosis. In addition to the role p53 protein plays in mediating a cell cycle arrest in G1 following DNA damage, p53 also performs functions critical for removal of damaged cells by initiating apoptosis in certain physiological situations. Cells which express deregulated c-myc are sensitized to apoptosis following various growth suppressing stimuli and these observations have provided new insights into how apoptosis-suppressing genes such as mutant p53, bcl-2 and bcr-abl may cooperate during transformation and how they might influence the sensitivity of cells to radiation and chemotherapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology*
  • Genes, Tumor Suppressor / physiology*
  • Humans
  • Oncogenes / physiology*