Humoral immune response in infants after BCG vaccination

Tuber Lung Dis. 1995 Jun;76(3):248-53. doi: 10.1016/s0962-8479(05)80013-9.


Setting: Child welfare division of a university-based department of pediatrics in Turkey.

Objective: To determine specific IgM and IgG response after BCG vaccination.

Design: Prospective, randomized trial.

Methods: Serum samples of 66 infants were taken before and at 2, 4, 6 and 15 months after vaccination. 35 infants were vaccinated at the first month and 31 at the second month after delivery. An ELISA assay was performed using PPD antigen.

Results: IgM antibodies increased significantly (P < 0.05) during the post-vaccination period. On the other hand IgG antibodies decreased in the second month after vaccination. At the fourth month the IgG level began to rise continuously (P < 0.01). The infants who were vaccinated at the second month showed a higher IgM response at the second and fourth month than those vaccinated in the first month (P < 0.05), but the difference was not visible thereafter (P > 0.05). 52 infants (78%) were tuberculin positive 8 weeks after vaccination.

Conclusion: Anti-PPD IgM and IgG levels rise progressively in BCG-vaccinated infants.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • BCG Vaccine / administration & dosage
  • BCG Vaccine / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G / blood*
  • Immunoglobulin M / blood*
  • Infant
  • Infant, Newborn
  • Male
  • Prospective Studies
  • Tuberculin / immunology*
  • Tuberculin Test
  • Tuberculosis / immunology*
  • Tuberculosis / prevention & control


  • BCG Vaccine
  • Immunoglobulin G
  • Immunoglobulin M
  • Tuberculin