Urinary albumin fragments as a new clinical parameter for the early detection of diabetic nephropathy

Intern Med. 1995 Jun;34(6):463-8. doi: 10.2169/internalmedicine.34.463.

Abstract

Urinary albumin fragments (uAF) from patients with NIDDM were analyzed as a possible factor in the early discovery of diabetic nephropathy before emergence of microalbuminuria. SDS-PAGE and immunoblot assay were employed for detection of uAF. Samples from 252 patients with NIDDM, 158 patients with non-diabetic diseases, and 48 healthy volunteers were examined; uAF were detected in 139 (55.2%), 94 (59.5%), only one (2.1%), respectively. In diabetic patients with normoalbuminuria, uAF were detected in 48 out of 159 cases (30.2%). Two years after the initial study, 3 of the 17 diabetic patients (17.6%) with normoalbuminuria and uAF showed micro- or macroalbuminuria. It was concluded that detection of uAF might be useful for the early detection of diabetic nephropathy in NIDDM.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Albuminuria / etiology
  • Albuminuria / urine*
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / urine*
  • Diabetic Nephropathies / complications
  • Diabetic Nephropathies / diagnosis*
  • Diabetic Nephropathies / urine
  • Enzyme-Linked Immunosorbent Assay
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Peptide Fragments / urine*
  • Reproducibility of Results

Substances

  • Peptide Fragments