Significance of urinalysis for subsequent kidney and urinary tract disorders in mass screening of adults

Intern Med. 1995 Jun;34(6):475-80. doi: 10.2169/internalmedicine.34.475.


To evaluate dipstick urinalysis as a predictor of subsequent kidney and urinary tract disorders in apparently healthy adults, we designed a cross-sectional, prospective, and retrospective study within a cohort. The severity of proteinuria was significantly (p < 0.01) associated with the amount of pathological casts, whereas hematuria without proteinuria was not. The frequency of subsequent serum creatinine increase (0.3 mg/dl/5 years or more) was significantly enhanced (from 0.4% to 7.3% along with the severity of proteinuria, whereas it was not related to the severity of hematuria. Patients who subsequently developed renal failure and glomerulonephritis exhibited hematuria (11.1-32.1%) less frequent than proteinuria (62.3-83.3%). Even those with renal tumors or stones showed infrequent (14.3-27.9%) hematuria. Thus, urine protein and occult blood have different implications in mass screening.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cohort Studies
  • Creatinine / blood
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Diseases / blood
  • Kidney Diseases / diagnosis*
  • Kidney Diseases / epidemiology
  • Male
  • Mass Screening / methods*
  • Middle Aged
  • Prevalence
  • Prognosis
  • Prospective Studies
  • Reagent Strips*
  • Retrospective Studies
  • Urinalysis / methods*
  • Urologic Diseases / blood
  • Urologic Diseases / diagnosis*
  • Urologic Diseases / epidemiology


  • Reagent Strips
  • Creatinine