The molecular basis of fragile sites in human chromosomes

Curr Opin Genet Dev. 1995 Jun;5(3):323-7. doi: 10.1016/0959-437x(95)80046-8.


Fragile sites on chromosomes have been classified into a number of groups according to their frequency and the conditions required to induce them. A number of the rare folate-sensitive fragile sites have been characterized and shown to be amplified methylated CCG trinucleotide repeats. One common fragile site has been partly characterized and appears to be a region of fragility, rather than a single site.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aphidicolin / pharmacology
  • Chromosome Fragile Sites
  • Chromosome Fragility*
  • Chromosomes, Human / chemistry
  • Chromosomes, Human / genetics*
  • Culture Techniques / methods
  • Gene Expression Regulation
  • Genes
  • Humans
  • Mutation
  • Repetitive Sequences, Nucleic Acid
  • Sequence Analysis, DNA


  • Aphidicolin