Growth-phase regulation of plasmid virulence genes in Salmonella

Trends Microbiol. 1995 Jul;3(7):275-9. doi: 10.1016/s0966-842x(00)88944-1.


Virulence genes in the genus Salmonella are regulated by growth phase and by environmental signals, which allows a sequential program of expression during infection. Conditions that promote the expression of loci required in systemic infection, including the plasmid-encoded spv genes, are the opposite of the factors that induce genes involved in the invasion of epithelial cells in the gastrointestinal tract.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Bacterial*
  • Humans
  • Plasmids*
  • Salmonella / genetics
  • Salmonella / growth & development
  • Salmonella / pathogenicity*
  • Virulence / genetics