Renal toxicity of albumin and other lipoproteins

Curr Opin Nephrol Hypertens. 1995 Jul;4(4):369-73. doi: 10.1097/00041552-199507000-00015.


Proteinuria may be an independent risk factor for nephrosclerosis. One potential mechanism has emerged with the finding that lipoproteins, including albumin, modulate the biology of mesangial cells and proximal tubular epithelial cells when internalized. Consequent alterations in renal-cell lipid metabolism may underlie some of these effects.

Publication types

  • Review

MeSH terms

  • Albumins / toxicity*
  • Animals
  • Humans
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / pathology
  • Lipoproteins / toxicity*
  • Proteinuria / chemically induced


  • Albumins
  • Lipoproteins