Lymphopoiesis. Transcription factors controlling B-cell development

Curr Biol. 1995 Jun 1;5(6):605-8. doi: 10.1016/s0960-9822(95)00121-7.

Abstract

Two structurally dissimilar transcriptional regulators, E2A and Pax-5, have been shown to play essential roles in B-cell development; the p50 subunit of NF kappa B, by contrast, is required for normal immune responses.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Gene Expression Regulation, Developmental
  • Helix-Loop-Helix Motifs / physiology
  • Hematopoiesis / genetics
  • Hematopoiesis / physiology*
  • Immunologic Deficiency Syndromes / genetics
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Multigene Family
  • NF-kappa B / chemistry
  • NF-kappa B / genetics
  • NF-kappa B / physiology*
  • Nerve Tissue Proteins*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / physiology*
  • PAX5 Transcription Factor
  • TCF Transcription Factors
  • Trans-Activators / genetics
  • Trans-Activators / physiology*
  • Transcription Factor 4
  • Transcription Factor 7-Like 1 Protein
  • Transcription Factors*

Substances

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • DNA-Binding Proteins
  • NF-kappa B
  • Nerve Tissue Proteins
  • Nuclear Proteins
  • PAX5 Transcription Factor
  • Pax5 protein, mouse
  • TCF Transcription Factors
  • Tcf4 protein, mouse
  • Tcf7l1 protein, mouse
  • Trans-Activators
  • Transcription Factor 4
  • Transcription Factor 7-Like 1 Protein
  • Transcription Factors