Castration increases [125I]MK801 binding in the hippocampus of male rats

Brain Res. 1995 Jun 19;683(2):270-4. doi: 10.1016/0006-8993(95)00384-3.


This study examines the effect of castration and androgen replacement on [125I]MK801 binding in the hippocampus. In castrated male rats, [125I]MK801 binding was significantly increased in both the stratum oriens and radiatum and the pyramidal cell layer of CA1. In contrast, no increase in [125I]MK801 binding was observed in the stratum oriens and radiatum of CA1 of castrated rats that were treated with dihydrotestosterone. No change in [125I]MK801 binding was observed in the CA3 region or dentate gyrus after castration. The observed increase in [125I]MK801 binding in pyramidal cell neurons within CA1 suggests that androgens may potentially affect hippocampal function by modulating pyramidal cell NMDA receptors.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Androgens / deficiency
  • Androgens / metabolism
  • Animals
  • Autoradiography
  • Dizocilpine Maleate / metabolism*
  • Dizocilpine Maleate / pharmacology
  • Hippocampus / metabolism*
  • Iodine Radioisotopes
  • Male
  • Orchiectomy*
  • Rats
  • Rats, Inbred F344
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors*


  • Androgens
  • Iodine Radioisotopes
  • Receptors, N-Methyl-D-Aspartate
  • Dizocilpine Maleate