Loss of neonatal hypoxia tolerance after prenatal nicotine exposure: implications for sudden infant death syndrome

Brain Res Bull. 1995;38(1):69-75. doi: 10.1016/0361-9230(95)00073-n.


Maternal cigarette smoking has a high correlation with sudden Infant Death Syndrome, a condition in which cardiorespiratory failure occurs during an hypoxic episode, as in sleep apnea. Pregnant rats were given nicotine infusions of 2 or 6 mg/kg/day throughout gestation, regimens that produce plasma nicotine levels spanning the range in smokers. The day after birth, animals in the high dose group displayed excessive mortality during hypoxic challenge. These animals were found to be deficient in an essential response component, namely adrenomedullary catecholamine release that is required to maintain neonatal cardiac rhythm during hypoxia; the defect was in adrenal cell function rather than in altered innervation or nicotinic receptor desensitization. We also examined brainstem and forebrain noradrenergic mechanisms that are involved in neonatal respiratory control. The nicotine group showed suppressed spontaneous neuronal activity, but were hyperresponsive to hypoxia. As these projections are inhibitory for respiration, the nicotine-induced sensitization would be expected to contribute to respiratory arrest during hypoxia. Prenatal nicotine exposure may thus provide a useful animal model with which to study the physiological mechanisms that underlie Sudden Infant Death Syndrome, while at the same time providing a biological explanation for the association of the syndrome with smoking.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Glands / metabolism
  • Animals
  • Animals, Newborn / physiology
  • Brain Chemistry / drug effects
  • Catecholamines / metabolism
  • Female
  • Humans
  • Hypoxia, Brain / metabolism
  • Hypoxia, Brain / physiopathology*
  • Infant
  • Infant, Newborn
  • Myocardium / metabolism
  • Nicotine / toxicity*
  • Nicotinic Agonists / toxicity*
  • Norepinephrine / metabolism
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Adrenergic / metabolism
  • Sudden Infant Death / etiology*


  • Catecholamines
  • Nicotinic Agonists
  • Receptors, Adrenergic
  • Nicotine
  • Norepinephrine