A carboxylesterase from the parasitic nematode Ascaris suum homologous to the intestinal-specific ges-1 esterase of Caenorhabditis elegans

Comp Biochem Physiol B Biochem Mol Biol. 1994 Oct-Nov;109(2-3):225-36. doi: 10.1016/0305-0491(94)90006-x.


We have identified a carboxylesterase in A. suum that appears to be the homolog of the gut-specific C. elegans ges-1 enzyme. The A. suum esterase was purified and its N-terminal sequence found to be 50% identical to the C. elegans ges-1 protein. We have used isoelectric focusing analysis to demonstrate that, unlike the C. elegans ges-1 esterase, the A. suum enzyme is not restricted to the gut but is expressed in a wide range of tissues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Ascaris suum / enzymology*
  • Caenorhabditis elegans / enzymology*
  • Caenorhabditis elegans Proteins*
  • Carboxylesterase
  • Carboxylic Ester Hydrolases / chemistry*
  • Female
  • Intestines / enzymology*
  • Molecular Sequence Data
  • Organ Specificity
  • Sequence Homology, Amino Acid


  • Caenorhabditis elegans Proteins
  • Carboxylic Ester Hydrolases
  • ges-1 protein, C elegans
  • Carboxylesterase