"Geometric clutch" hypothesis of axonemal function: key issues and testable predictions

Cell Motil Cytoskeleton. 1995;31(1):1-8. doi: 10.1002/cm.970310102.

Abstract

The Geometric Clutch hypothesis integrates a large body of seemingly disconnected analytical measurements and observations into one conceptual framework. It remains to be established whether certain key requirements of the hypothesis are actual attributes of real axonemes. The hypothesis is rich in predictive value, as its fundamental working elements are developed directly from physical properties and structures of the axoneme. Exploration of these predictions will serve to confirm or reject the hypothesis itself, but even more importantly, may contribute to elucidation of the principles underlying ciliary and flagellar functioning.

MeSH terms

  • Cilia / physiology*
  • Cilia / ultrastructure
  • Cross-Linking Reagents
  • Dyneins / physiology
  • Flagella / physiology*
  • Flagella / ultrastructure
  • Movement / physiology*

Substances

  • Cross-Linking Reagents
  • Dyneins