Serum neopterin concentrations in Wegener's granulomatosis correlate with vasculitis activity

Clin Exp Rheumatol. 1995 May-Jun;13(3):353-6.

Abstract

Raised serum neopterin concentrations were found in 13 of 27 patients (47%) with Wegener's granulomatosis. The neopterin concentrations significantly correlated with the Birmingham Vasculitis Activity Score as well as with the erythrocyte sedimentation rate and C-reactive protein. High serum neopterin levels were also associated with infectious complications. The finding of increased neopterin concentrations in patients with Wegener's granulomatosis supports the role of cell-mediated immunity and particularly of activated macrophages in the pathogenesis of the disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies / blood
  • Biopterin / analogs & derivatives*
  • Biopterin / blood
  • Disease Progression
  • Female
  • Fluorescent Antibody Technique
  • Follow-Up Studies
  • Granulomatosis with Polyangiitis / blood*
  • Granulomatosis with Polyangiitis / immunology
  • Humans
  • Male
  • Neopterin
  • Radioimmunoassay

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Autoantibodies
  • Biopterin
  • Neopterin