A survey of beta-lactamase-producing Haemophilus influenzae. An evaluation of 5750 isolates

Diagn Microbiol Infect Dis. 1995 Apr;21(4):223-5. doi: 10.1016/0732-8893(95)00028-9.


Previous studies have reported that 15%-34% of Haemophilus influenzae produce beta-lactamase. A surveillance program was developed by SmithKline Beecham Clinical Laboratories to determine the current percentage of beta-lactamase-producing H. influenzae from five selected geographic locations in the United States. In 1993, results of 5750 isolates from specimens submitted to five reference clinical laboratories were evaluated. Data were collected from 29 states and the District of Columbia. The percentages of beta-lactamase-producing H. influenzae was 33% and ranged from 22%-40% for the individual states.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Confidence Intervals
  • Haemophilus Infections / epidemiology
  • Haemophilus Infections / microbiology*
  • Haemophilus influenzae / enzymology*
  • Humans
  • Infant
  • Middle Aged
  • Molecular Epidemiology
  • United States / epidemiology
  • beta-Lactamases / biosynthesis*


  • beta-Lactamases