Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus

Diabetes Res Clin Pract. 1995 Mar;27(3):181-8. doi: 10.1016/0168-8227(95)01040-k.

Abstract

A cross-sectional survey was carried out in a New Zealand Polynesian and Caucasian workforce of 5677 staff aged 40-64 years to determine whether serum concentrations of 25-hydroxyvitamin D3 are altered in people with newly diagnosed diabetes mellitus and impaired glucose tolerance (IGT). Serum 25-hydroxyvitamin D3 concentration was significantly lower in newly detected cases with diabetes and IGT (n = 238) compared with controls individually matched by sex, age (+/- 2 years), ethnicity, and date of interview (mean (S.D.): 69 (31) vs. 76 (34) nmol/l; P = 0.0016). Among controls, serum concentrations were significantly lower in Maori (mean (S.E.) = 65 (5) nmol/l; P = 0.0013) and Pacific Islanders (59 (4) nmol/l; P = 0.0001) compared with Europeans (82 (3) nmol/l), after adjusting for age, sex, and time of year. We conclude that diabetes and IGT are associated with low serum concentrations of 25-hydroxyvitamin D3 and that low concentrations of this hormone in New Zealand Polynesians may partly explain their increased prevalence of diabetes/IGT compared with Europeans.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asia / epidemiology
  • Blood Pressure
  • Calcifediol / blood*
  • Cross-Sectional Studies
  • Diabetes Mellitus / blood*
  • Diabetes Mellitus / physiopathology
  • Ethnic Groups
  • Europe / ethnology
  • European Continental Ancestry Group
  • Female
  • Glucose Intolerance / blood*
  • Glucose Intolerance / physiopathology
  • Humans
  • Hypertension / complications
  • Hypertension / physiopathology
  • Male
  • Middle Aged
  • New Zealand
  • Odds Ratio
  • Periodicity
  • Polynesia / ethnology
  • Reference Values
  • Seasons
  • Sex Characteristics

Substances

  • Calcifediol