Colorectal mini-de novo carcinoma: a reality in Germany too

Endoscopy. 1995 May;27(4):286-90. doi: 10.1055/s-2007-1005694.


Background and study aims: Based on Japanese case studies, we examined whether colorectal mini-de novo carcinoma also occurs outside Japan. We defined mini-de novo carcinomas as carcinomas infiltrating the submucosa, with a maximum diameter of 10 mm, and with no evidence of precursive adenomatous tissue.

Patients and methods: Between 1988 and 1994, we diagnosed carcinomas of this type in polypectomy and surgical resection specimens from 155 patients. These mini-de novo carcinomas did not differ from carcinomas arising from adenomas in terms of patient age (median 67.1 years), sex distribution (men: women 0.96:1), or location--they occurred primarily in the sigmoid (53%) and rectum (27.3%).

Results: Most of the mini-de novo carcinomas were macroscopically of the polypoid type (59.4%); flat, elevated carcinomas were also relatively frequent, including those with a central concave depression (21.9%) and those without a depression (12.3%). Histologically, all of the lesions without exception were adenocarcinomas (grade 1: 28.4%, grade 2: 65.8%, grade 3: 5.8%). There was carcinomatous invasion of submucosal lymphatic or blood vessels in 20%.

Conclusions: Our analysis shows that colorectal mini-de novo carcinoma is not a purely Japanese phenomenon, and that these carcinomas are being diagnosed with increasing frequency as the awareness of their existence and macroscopic growth characteristics increases.

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Carcinoma in Situ / diagnosis
  • Carcinoma in Situ / epidemiology*
  • Carcinoma in Situ / pathology*
  • Colorectal Neoplasms / diagnosis
  • Colorectal Neoplasms / epidemiology*
  • Colorectal Neoplasms / pathology*
  • Endoscopy, Gastrointestinal
  • Female
  • Germany / epidemiology
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Registries
  • Sex Distribution