The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance

FEBS Lett. 1995 Sep 11;371(3):321-3. doi: 10.1016/0014-5793(95)00931-x.


The interaction of Fas (Apo-1) and TNF receptor-1 with their respective ligands can lead to cell death. The so-called death domain, a sequence motif present in the cytoplasmic portion of the two receptors, has been identified as a critical structural element involved in signal transduction that leads to apoptosis. Here we describe several additional proteins which contain a death domain. Novel members of this family include proteins known to be implicated not only in apoptosis but also in neuron guidance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Apoptosis*
  • Axons*
  • Base Sequence
  • Binding Sites
  • Cell Movement
  • Databases, Factual
  • Humans
  • Molecular Sequence Data
  • Receptors, Tumor Necrosis Factor / metabolism*
  • fas Receptor / metabolism*


  • Receptors, Tumor Necrosis Factor
  • fas Receptor

Associated data

  • GENBANK/L36529
  • GENBANK/L41690
  • GENBANK/S47168
  • GENBANK/U21731
  • GENBANK/U25994
  • GENBANK/X76104
  • GENBANK/X84709