41 kilobases of analyzed sequence from the pseudoautosomal and sex-determining regions of the short arm of the human Y chromosome

Genomics. 1995 May 20;27(2):306-11. doi: 10.1006/geno.1995.1047.


Determination of 41.2 kb of Y chromosome genomic sequence has been made from a cosmid that spans the Yp pseudoautosomal boundary and includes 18.5 kb of sequence from the patient-defined sex-determining region of the Y chromosome. An AceDB database of the sequence and the analysis data have been produced as a resource for studies of the evolution and population genetics of the Y chromosome. Comparison of the 18.5 kb from the sex determining region to the sex determining region of mouse does not locate any areas of similarity outside SRY/Sry. Indeed, no coding regions other than those previously reported can be detected anywhere in the 41 kb. The Y-specific and pseudoautosomal portions of this sequence have different repeat sequence and GC contents: this may have relevance both to the events defining the pseudoautosomal boundary and to the course of sequence evolution in the absence of recombination.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping
  • Cosmids
  • DNA Transposable Elements
  • DNA-Binding Proteins / genetics*
  • Humans
  • Male
  • Mice
  • Nuclear Proteins*
  • Repetitive Sequences, Nucleic Acid
  • Sex Determination Analysis
  • Sex-Determining Region Y Protein
  • Transcription Factors*
  • Y Chromosome / genetics*


  • DNA Transposable Elements
  • DNA-Binding Proteins
  • Nuclear Proteins
  • SRY protein, human
  • Sex-Determining Region Y Protein
  • Sry protein, mouse
  • Transcription Factors

Associated data

  • GENBANK/X96421