Abstract
Helix-loop-helix proteins contain stretches of DNA that encode two amphipathic alpha-helices joined by a loop structure and are involved in protein dimerization and transcriptional regulation essential to a variety of cellular processes. CHUK, a newly described conserved helix-loop-helix ubiquitous kinase, was mapped by somatic cell hybrid analyses to human Chr 10q24-q25. Chuk and a related sequence, Chuk-rs1, were mapped to mouse chromosomes 19 and 16, respectively, by a combination of somatic cell hybrid, recombinant inbred, and backcross analyses.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chromosome Mapping*
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Chromosomes
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Chromosomes, Human, Pair 10*
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Cricetinae
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DNA, Complementary / chemistry
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Helix-Loop-Helix Motifs / genetics*
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Humans
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I-kappa B Kinase
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Leucine Zippers / genetics*
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Mice
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Mice, Inbred Strains
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Molecular Sequence Data
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Protein Serine-Threonine Kinases / genetics*
Substances
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DNA, Complementary
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Protein Serine-Threonine Kinases
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CHUK protein, human
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Chuk protein, mouse
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I-kappa B Kinase
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IKBKB protein, human
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IKBKE protein, human
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Ikbkb protein, mouse
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Ikbke protein, mouse