Risperidone treatment of children and adolescents with chronic tic disorders: a preliminary report

J Am Acad Child Adolesc Psychiatry. 1995 Sep;34(9):1147-52. doi: 10.1097/00004583-199509000-00011.


Objective: The purpose of this trial was to investigate the short-term safety and efficacy of risperidone in the treatment of chronic tic disorders in children and adolescents.

Method: This was an 11-week open-label trial and included seven subjects (five boys and two girls) with a mean age of 12.9 +/- 1.9 years. The sample included five patients with Tourette's syndrome and two with chronic motor tic disorder. The children were seen at baseline and for two follow-up visits. Three children had a comorbid diagnosis of obsessive-compulsive disorder (OCD).

Results: Clinical response, as measured by the Yale Global Tic Severity Scale and the Children's version of the Yale-Brown Obsessive Compulsive Scale, revealed a statistically significant reduction in tic scores ranging from 26% [corrected] to 66%. One of three children with comorbid OCD showed substantial improvement; the other two subjects showed no change. The most frequent side effect was weight gain, which ranged from 8 to 14 lb.

Conclusions: Risperidone, a neuroleptic with both serotonin- and dopamine-blocking properties, appears to be effective in reducing tic frequency and intensity in children and adolescents with chronic tic disorders.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Antipsychotic Agents / therapeutic use
  • Attention Deficit Disorder with Hyperactivity / complications
  • Attention Deficit Disorder with Hyperactivity / drug therapy
  • Child
  • Chronic Disease
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Male
  • Obsessive-Compulsive Disorder / complications
  • Obsessive-Compulsive Disorder / drug therapy
  • Pilot Projects
  • Risperidone / administration & dosage
  • Risperidone / adverse effects
  • Risperidone / therapeutic use*
  • Severity of Illness Index
  • Tic Disorders / complications
  • Tic Disorders / drug therapy*
  • Tourette Syndrome / complications
  • Tourette Syndrome / drug therapy
  • Weight Gain


  • Antipsychotic Agents
  • Risperidone