The pathology of frozen shoulder. A Dupuytren-like disease

J Bone Joint Surg Br. 1995 Sep;77(5):677-83.


Of 935 consecutive patients referred with shoulder pain, 50 fitted the criteria for primary frozen shoulder. Twelve patients who failed to improve after conservative treatment and manipulation had excision of the coracohumeral ligament and the rotator interval of the capsule. The specimens were examined histologically, using special stains for collagen. Immunocytochemistry was performed with monoclonal antibodies against leucocyte common antigen (LCA, CD45) and a macrophage/synovial antigen (PGMI, CD68) to assess the inflammatory component, and vimentin and smooth-muscle actin to evaluate fibroblasts and myofibroblasts. Our histological and immunocytochemical findings show that the pathological process is active fibroblastic proliferation, accompanied by some transformation to a smooth muscle phenotype (myofibroblasts). The fibroblasts lay down collagen which appears as a thick nodular band or fleshy mass. These appearances are very similar to those in Dupuytren's disease of the hand, with no inflammation and no synovial involvement. The contracture acts as a check-rein against external rotation, causing loss of both active and passive movement.

MeSH terms

  • Adult
  • Aged
  • Collagen / analysis
  • Connective Tissue Diseases / complications
  • Connective Tissue Diseases / pathology*
  • Connective Tissue Diseases / surgery
  • Contracture / pathology*
  • Contracture / physiopathology
  • Contracture / surgery
  • Dupuytren Contracture / complications
  • Dupuytren Contracture / pathology
  • Female
  • Fibroblasts / pathology
  • Humans
  • Ligaments, Articular / pathology
  • Male
  • Middle Aged
  • Range of Motion, Articular
  • Shoulder Joint / pathology*
  • Shoulder Joint / physiopathology
  • Shoulder Joint / surgery
  • Synovial Membrane / pathology
  • Vimentin / analysis


  • Vimentin
  • Collagen