Abstract
Spiganthine [1] was isolated as the main cardioactive principle from medicinally used extracts of Spigelia anthelmia. Its structure was established by spectroscopic methods. The biological effect of spiganthine is characterized by a delay in contraction development of the heart muscle.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cardiotonic Agents / chemistry
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Cardiotonic Agents / isolation & purification*
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Cardiotonic Agents / pharmacology*
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Electric Stimulation
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Guinea Pigs
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Heart / drug effects*
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In Vitro Techniques
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Myocardial Contraction / drug effects
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Papillary Muscles / drug effects
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Plants, Medicinal / chemistry*
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Ryanodine / analogs & derivatives*
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Ryanodine / chemistry
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Ryanodine / isolation & purification
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Ryanodine / pharmacology
Substances
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Cardiotonic Agents
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spiganthine
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Ryanodine