Spiganthine, the cardioactive principle of Spigelia anthelmia

J Nat Prod. 1995 Jul;58(7):1092-6. doi: 10.1021/np50121a019.

Abstract

Spiganthine [1] was isolated as the main cardioactive principle from medicinally used extracts of Spigelia anthelmia. Its structure was established by spectroscopic methods. The biological effect of spiganthine is characterized by a delay in contraction development of the heart muscle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cardiotonic Agents / chemistry
  • Cardiotonic Agents / isolation & purification*
  • Cardiotonic Agents / pharmacology*
  • Electric Stimulation
  • Guinea Pigs
  • Heart / drug effects*
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Myocardial Contraction / drug effects
  • Papillary Muscles / drug effects
  • Plants, Medicinal / chemistry*
  • Ryanodine / analogs & derivatives*
  • Ryanodine / chemistry
  • Ryanodine / isolation & purification
  • Ryanodine / pharmacology

Substances

  • Cardiotonic Agents
  • spiganthine
  • Ryanodine