Activated protein C resistance in a neonate with venous thrombosis

J Pediatr. 1995 Oct;127(4):645-8. doi: 10.1016/s0022-3476(95)70131-1.


A term infant had a life-threatening inferior venal caval thrombosis during the first 24 hours of life. The plasma from the infant and his mother was found to be resistant to activated protein C and to be heterozygous for the factor V mutation (FV Leiden) associated with this disorder. The presence of this hereditary disorder should be considered in infants with thrombosis and in infants with conditions predisposing them to thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Antithrombin III
  • Factor V / analysis
  • Factor V / genetics
  • Gene Amplification
  • Genotype
  • Humans
  • Infant, Newborn*
  • Male
  • Mutagenesis
  • Partial Thromboplastin Time
  • Pedigree
  • Polymerase Chain Reaction
  • Protein C / analysis*
  • Prothrombin Time
  • Thrombophlebitis / diagnosis*
  • Thrombophlebitis / genetics*


  • Protein C
  • Antithrombin III
  • Factor V