Gastric emptying in acute overdose: a prospective randomised controlled trial

Med J Aust. 1995 Oct 2;163(7):345-9.


Objective: To test the hypothesis that administration of activated charcoal is as efficacious and safe as the combination regimen of gastric emptying plus charcoal in adults after acute oral overdose.

Design: Prospective randomised controlled trial, with subjects presenting on odd-numbered dates allocated to the emptied group (E), and those on even-numbered dates to the not-emptied group (NE).

Setting: Princess Alexandra Hospital, Brisbane (a tertiary referral hospital), which serves an adult urban community, between 4 January 1988 and 11 June 1990.

Subjects: Consecutive patients (13 years or older) who presented to the Emergency Department after ingesting an overdose of one or more compounds able to be adsorbed by activated charcoal.

Interventions: All patients received charcoal by the oral or nasogastric route. Those in the E group also had gastric emptying by ipecac-induced emesis or gastric lavage.

Outcome measures: Clinical course during the first six hours after treatment began, length of hospital stay, complications.

Results: 876 patients were eligible for the study. There were no significant differences between the E and NE groups in age and sex distribution, severity of the overdose or other characteristics, except the mean interval between presentation and administration of charcoal (91 min [SD, 52] for E group and 55 [SD, 41] for NE group; P = 0.0001). There were no significant differences between the E and NE groups in outcome, even when the groups were stratified for severity of the overdose or into subgroups that presented sooner or later than one hour after ingestion.

Conclusions: Gastric emptying can be omitted from the treatment protocol for adults after acute oral overdose.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Charcoal / therapeutic use*
  • Combined Modality Therapy
  • Drug Overdose / complications
  • Drug Overdose / therapy*
  • Female
  • Gastric Lavage*
  • Humans
  • Ipecac / therapeutic use*
  • Length of Stay
  • Male
  • Prospective Studies
  • Risk Factors
  • Time Factors
  • Treatment Outcome


  • Charcoal
  • Ipecac