This descriptive study evaluates and compares the effectiveness of music, presented both aurally and vibrotactilely, in reducing agitation and physiological instability following a stress-producing intervention (suctioning) in infants with bronchopulmonary dysplasia. Heart rate, oxygen saturation levels, level of arousal, stressful facial expressions, and autonomic indicators were recorded for each of four preterm infants. All infants experienced a reduction in the level of arousal during the taped music intervention when compared with the control condition. Three infants spent an increased amount of time in a quiet alert state and had improved oxygen saturation levels during the vibrotactile intervention. All infants spent more time sleeping during the taped music condition than without music or with the vibrotactile intervention. Results suggest that music is effective in reducing stress-related behaviors for some infants.