Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

Nature. 1995 Sep 28;377(6547):351-4. doi: 10.1038/377351a0.


The lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12/Notch family of receptors for intercellular signals that specify cell fate. By screening for suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which appears to function in receiving cells to facilitate signalling mediated by lin-12 and glp-1. The sel-12 gene encodes a protein with multiple transmembrane domains, and is similar to S182, which has been implicated in early-onset familial Alzheimer's disease. The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Alzheimer Disease / genetics*
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans Proteins*
  • Conserved Sequence
  • DNA Primers
  • Female
  • Genes, Helminth
  • Helminth Proteins / genetics*
  • Helminth Proteins / metabolism
  • Humans
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism
  • Molecular Sequence Data
  • Mutagenesis
  • Receptors, Notch
  • Signal Transduction*
  • Suppression, Genetic
  • Vulva / embryology


  • Caenorhabditis elegans Proteins
  • DNA Primers
  • Helminth Proteins
  • Lin-12 protein, C elegans
  • Membrane Proteins
  • Receptors, Notch
  • SEL-12 protein, C elegans

Associated data

  • GENBANK/U35660