An integrated physical map of human chromosome 16

Nature. 1995 Sep 28;377(6547 Suppl):335-65. doi: 10.1038/377335a0.


We describe an integrated physical, genetic and cytogenetic map of human chromosome 16 comprising both a low-resolution megaYAC map and a high-resolution cosmid contig/miniYAC map, which provides nearly complete coverage of the euchromatic arms of the chromosome. The physical map is anchored to a high-resolution cytogenetic breakpoint map and is integrated with genetic and gene transcript maps of the chromosome by sequence-tagged sites and clone hybridizations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Chromosomes, Artificial, Yeast
  • Chromosomes, Human, Pair 16*
  • Cosmids
  • DNA, Complementary
  • Evaluation Studies as Topic
  • Genetic Markers
  • Humans
  • Hybrid Cells
  • Mice
  • Nucleic Acid Hybridization
  • Sequence Tagged Sites


  • DNA, Complementary
  • Genetic Markers