Cytokine receptor signalling

Nature. 1995 Oct 19;377(6550):591-4. doi: 10.1038/377591a0.


Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex. Among these are the signal transducers and activators of transcription (STATs), a family of transcription factors that contribute to the diversity of cytokine responses.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Transformation, Neoplastic
  • Gene Expression Regulation
  • Molecular Sequence Data
  • Phosphoprotein Phosphatases / metabolism
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Cytokine / metabolism*
  • Signal Transduction*
  • Trans-Activators / metabolism


  • Receptors, Cytokine
  • Trans-Activators
  • Protein-Tyrosine Kinases
  • Phosphoprotein Phosphatases