Role of the serotonergic system in the forced swimming test

Neurosci Biobehav Rev. Fall 1995;19(3):377-95. doi: 10.1016/0149-7634(94)00050-b.


The effect of manipulations aimed at modifying the function of the 5-HT system has been reviewed. 5-HT uptake inhibitors are devoid of any activity in rats and induce an anti-immobility effect in mice. The so-called 5-HT1A agonists reduce the immobility time with some differences in mice and rats, mice being less sensitive. None of the procedure aimed at reducing 5-HT function reduced immobility time. Therefore, the 5-HT system does not play a tonic role in animals performing the forced swimming test. The involvement of possible brain regions mediating the anti-immobility effects of 5-HT mimetic drugs has been discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Antidepressive Agents / pharmacology
  • Depression / drug therapy
  • Depression / physiopathology*
  • Male
  • Mice
  • Rats
  • Serotonin / metabolism
  • Serotonin / physiology*
  • Serotonin Receptor Agonists / pharmacology*
  • Serotonin Uptake Inhibitors / pharmacology
  • Swimming


  • Antidepressive Agents
  • Serotonin Receptor Agonists
  • Serotonin Uptake Inhibitors
  • Serotonin